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Below, you’ll find publications originating from LiME, organized by publication type and year. If you have questions about any specific publication, please feel free to contact the PI or the corresponding first author by email, and we will respond as soon as possible.
Below, you’ll find publications originating from LiME, organized by publication type and year. If you have questions about any specific publication, please feel free to contact the PI or the corresponding first author by email, and we will respond as soon as possible.
Research Articles
Research Articles
2027
2027
Before joining UGA
Before joining UGA
Li, C., Zhao, C., Deng, K., Huang, D., Varongchayakul, C., Baerwald, J., Dan, Q., Turumtay, E. A., Baidoo, E. E K, Northen, T. R, Chen, A., Li, J., Cheng, N., Qin, N., Klass, S., Hou, J., Keasling, J.D., Engineered Polyketide Synthase Platform Provides Access to Uncharted Biochemical Diversity. Nature Catalysis, Under Revision.
Hwang, S.#, Li, C.#, Chen, Y., Gin, J., Petzold, C., Zhao, C., Chen, A., .Lee, N.*, Keasling, J. D*. Heterologous methylmalonyl-CoA pathway enhances malonyl-CoA supply and derived products biosynthesis in Pseudomonas putida. Trends in Biotechnology, Under revision.
Huang, D.#, Li, C.#, Chen, A., Varongchayakul, C., Zhao, C., Keasling, J. D. * Sustainable Biosynthesis of 4-Phenylbutyric Acid via Polyketide Synthase. Manuscript under submission.
Zhao, C., Hou, J., Huang, D., Varongchayakul, C., Cheng, N., Li, Y., Li, C*. and Keasling, J.D.*, 2026. Unlocking Microbial Access to Amino-substituted 4-Hydroxycoumarin Derivatives via Enzymatic Promiscuity and Metabolic Engineering. Metabolic Engineering, p.102541.
Klass, S.H., Wang, Z., Lanclos, N., Wesselkamper, M., Li, C., Baerwald, J., Pearson, A., Thomas, M., Hu, W., Schmidt, M., Chen, Y., Gin, J.W., Petzold, C.J., Keasling, J.D., 2026. ACS Synthetic Biology 15, 2887–2899.
Lee, N., Schmidt, M., Li, C., Filbin, C.J., Klass, S., Yaguchi, A., Fear, A.L., Backman, T.W.H., Abel, B.A., Kim, Y.-M., Kim, W.E., Johnson, C.W., Chen, Y., Gin, J.W., Petzold, C.J., Baidoo, E.E.K., Gao, Y., Burnet, M.C., Babnigg, G., Laible, P.D., Singer, C.A., Michener, W.E., Salvachúa, D., Garcia Martin, H., Haushalter, R.W., Keasling, J.D., 2025. Retrobiosynthesis of unnatural lactams via reprogrammed polyketide synthase. Nature Catalysis 8, 389–402.
Dan, Q., Chiu, Y., Lee, N., Pereira, J.H., Rad, B., Zhao, X., Deng, K., Rong, Y., Zhan, C., Chen, Y., Cheong, S., Li, C., Gin, J.W., Rodrigues, A., Northen, T.R., Backman, T.W.H., Baidoo, E.E.K., Petzold, C.J., Adams, P.D., Keasling, J.D., 2025. A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids. Nature Catalysis 8, 147–161.
Gan, Q.#, Jiang, T.#, Li, C., Gong, X., Zhang, J., Desai, B.K., Yan, Y., 2025. De novo biosynthesis of 4,6-dihydroxycoumarin in Escherichia coli. Green Chemistry 27, 3064–3076.
Zhan, C., Lan, G., Dan, Q., Qin, N., Pearson, A., Mellinger, P., Liu, Y., Wang, Z., Cheong, S., Dou, C., Li, C., Haushalter, R., Keasling, J.D., 2025. Hybrid biological-chemical strategy for converting polyethylene into a recyclable plastic monomer using engineered Corynebacterium glutamicum. Metabolic Engineering 90, 106–116.
Wang, J.#, Li, C.#, Jiang, T., Yan, Y., 2023. Biosensor-assisted titratable CRISPRi high-throughput (BATCH) screening for over-production phenotypes. Metabolic Engineering 75, 58–67.
Li, C.#, Zhou, Y.#, Zou, Y., Jiang, T., Gong, X., Yan, Y., 2023. Identifying, characterizing, and engineering a phenolic acid-responsive transcriptional factor from Bacillus amyloliquefaciens. ACS Synthetic Biology 12, 2382–2392.
Jiang, T., Teng, Y., Li, C., Gan, Q., Zhang, J., Zou, Y., Desai, B.K., Yan, Y., 2023. Establishing tunable genetic logic gates with versatile dynamic performance by varying regulatory parameters. ACS Synthetic Biology 12(12), 3730–3742.
Li, C., Zou, Y., Jiang, T., Zhang, J., Yan, Y., 2022. Harnessing plasmid replication mechanism to enable dynamic control of gene copy in bacteria. Metabolic Engineering 70, 67–78.
Wang, J., Jiang, T., Milligan, S., Zhang, J., Li, C., Yan, Y., 2022. Improving isoprenol production via systematic CRISPRi screening in engineered Escherichia coli. Green Chemistry 24, 6955–6964.
Jiang, T., Li, C., Zou, Y., Zhang, J., Gan, Q., Yan, Y., 2022. Establishing an Autonomous Cascaded Artificial Dynamic (AutoCAD) regulation system for improved pathway performance. Metabolic Engineering 74, 1–10.
Zou, Y.#, Li, C.#, Zhang, R., Jiang, T., Liu, N., Wang, J., Wang, X., Yan, Y., 2021. Exploring the tunability and dynamic properties of MarR-PmarO sensor system in Escherichia coli. ACS Synthetic Biology 10(8), 2076–2086.
Jiang, T., Li, C., Yan, Y., 2021. Optimization of a p-coumaric acid biosensor system for versatile dynamic performance. ACS Synthetic Biology 10(1), 132–144.
Li, C.#, Gao, X.#, Peng, X., Li, J., Bai, W., Zhong, J., He, M., Xu, K., Wang, Y., Li, C., 2020. Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self-responsive base/acid regulation. Microbial Cell Factories 19(1), 1–13.
Wang, J.#, Li, C.,#, Zou, Y., Yan, Y., 2020. Bacterial synthesis of C3–C5 diols via extending amino acid catabolism. Proceedings of the National Academy of Sciences 117(32), 19159–19167.
Yang, Y., Lin, Y., Wang, J., Wu, Y., Zhang, R., Cheng, M., Shen, X., Wang, J., Chen, Z., Li, C., Yuan, Q., Yan, Y., 2018. Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis. Nature Communications 9(1), 3043.
Jia, H., Sun, X., Sun, H., Li, C., Wang, Y., Feng, X., Li, C., 2016. Intelligent microbial heat-regulating engine (IMHeRE) for improved thermo-robustness and efficiency of bioconversion. ACS Synthetic Biology 5(4), 312–320.
Review Articles
Review Articles
2027
2027
Before joining UGA
Before joining UGA
Bhatia, S.K., Bhatia, S., Inda-Webb, M.E., Kourmentza, K., Moon, T.S., Singh, V., Ahuja, V., Li, J., Mehariya, S., Walia, A., Diao, J., Han, T., Kumar, J.V., Li, C., Toparlak, O.D., Wu, F., Zhao, J., 2024. Biotechnology for sustainable materials: Innovating today for a greener tomorrow. Biotechnology for Sustainable Materials 1, 3.
Jiang, T., Li, C., Teng, Y., Zhang, J., Logan, D.A., Yan, Y., 2023. Dynamic metabolic control: From the perspective of regulation logic. Synthetic Biology and Engineering 1(2), 10012.
Li, C., Jiang, T., Li, M., Zou, Y., Yan, Y., 2021. Fine-tuning gene expression for improved biosynthesis of natural products: From transcriptional to post-translational regulation. Biotechnology Advances, 107853.
Li, C., Zhang, R., Wang, J., Wilson, L.M., Yan, Y., 2020. Protein engineering for improving and diversifying natural product biosynthesis. Trends in Biotechnology 38(7), 729–744.
Jiang, T., Li, C., Teng, Y., Zhang, R., Yan, Y., 2020. Recent advances in improving metabolic robustness of microbial cell factories. Current Opinion in Biotechnology 66, 69–77.
Shen, X., Wang, J., Li, C., Yuan, Q., Yan, Y., 2019. Dynamic gene expression engineering as a tool in pathway engineering. Current Opinion in Biotechnology 59, 122–129.
Zhang, R., Li, C., Wang, J., Yan, Y., 2018. Microbial production of small medicinal molecules and biologics: From nature to synthetic pathways. Biotechnology Advances 36(8), 2219–2231.
Zhang, R., Li, C., Wang, J., Yan, Y., 2018. Microbial ligninolysis: Toward a bottom-up approach for lignin upgrading. Biochemistry 58(11), 1501–1510.
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